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The study of ancient DNA shows that the world was peopled via genocide, settler colonialism, rape, war, domination, slavery, murder. (David Reich's book on ancient DNA should be read by everyone.)

I have thought about what the Americas would be like without European colonization. Would the wheel and the horse be known in the Americas? Would the Aztecs have continued their cruel predation of tribes in central Mexico for slaves and human sacrifices?

Invariably, the isolation would not have lasted. And the history of meetings between societies possessing highly sophisticated tools and those not possessing them.

In terms of North America, it's important to remember that the tribes, like humans everywhere, were hell to each other. Keep in mind that the people in the Americas called "indigenous" are in fact from Siberia. So, a more accurate term for them would be Siberian-American.

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